Define and manage global shortcut keys, with Keyboard Tweaker
Keyboard Tweaker is a free program that will let you create and manage global Hotkeys to do various tasks.
Including special system multimedia functions, it will transform a normal keyboard with 101/102 keys into a multimedia keyboard handling with shortcuts the sound volume etc.
For example Ctrl+Alt+A may run one of the functions:
Speaker Volume Up; Speaker Volume Down; Speaker Mute; calculator, paint, solitaire, notepad or any other executable located on the hard drive; any kind of file with the associated program (like *.jpg); e-mails; URLs; local paths; network paths; Hide/Show the application.